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    Dr. Stephen M. Jodis, Dean
    The Herbert W. Boyer School of Natural Sciences, Mathematics, and Computing
    Phone: 724-805-2631

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  • Michael SierkDr. Michael Sierk

    Assistant Professor of Bioinformatics  

    Chemistry Department 
    N215, Sis and Herman Dupré Science Pavilion 

    (724) 805-2367

    Office hours:
    Posted on door


    B.S., Rice University
    Ph.D., Biophysics, University of Virginia

    Courses Taught

    BIN 218 Bioinformatics, Genomics, and Proteomics
    BIN 219 Biomedical Informatics
    BIN 357 Junior Bioinformatics Seminar
    BIN 358 Senior Bioinformatics Research 
    BIN 359 Senior Bioinformatics Seminar

    NSCI 230 Genes, Cells, and Computers
    NSCI 231 Genes, Cells, and Computers

    CH 101 General Chemistry I
    CH 103 General Chemistry I Laboratory
    CH 104 General Chemistry II Laboratory

    HSC 504 Biochemistry



    Sierk, M. L., Smoot, M. E., Bass, E. J., and Pearson, W. R. (2010) “Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments.” BMC Bioinformatics 11:146.
    Pearson, W. R. and Sierk, M. L. (2005) “The Limits of Protein Sequence Comparison?” Current Opinion in Structural Biology 15(3), 254-260.
    Sierk, M. L. and Kleywegt, G. J. (2004) “Déjà vu all over again - Finding and Analyzing Protein Structure Similarities.” Structure 12, 2103-2111.
    Sierk, M. L. and Pearson, W. R. (2004) “Sensitivity and selectivity in protein structure comparison.” Protein Science 13, 773-785.
    Sierk, M. L., Zhao, Q., and Rastinejad, F. (2001) “DNA deformability as a recognition feature in the RevErb response element.” Biochemistry 40, 12833-12843.
    Zhao, Q., Chasse, S. A., Devarakonda, S., Sierk, M. L., Ahvazi, B., and Rastinejad, F. (2000) “Structural basis of RXR-DNA interactions.” J. Mol. Biol. 296, 509-520.