Dr. Michael Sierk

Assistant Professor of Bioinformatics  

Chemistry Department 
N215, Sis and Herman Dupré Science Pavilion 

(724) 805-2367
michael.sierk@email.stvincent.edu  

Office hours:
Posted on door

Education

B.S., Rice University
Ph.D., Biophysics, University of Virginia

Courses Taught

BIN 218 Bioinformatics, Genomics, and Proteomics
BIN 219 Biomedical Informatics
BIN 357 Junior Bioinformatics Seminar
BIN 358 Senior Bioinformatics Research 
BIN 359 Senior Bioinformatics Seminar

NSCI 230 Genes, Cells, and Computers
NSCI 231 Genes, Cells, and Computers

CH 101 General Chemistry I
CH 103 General Chemistry I Laboratory
CH 104 General Chemistry II Laboratory

HSC 504 Biochemistry

Publications

Sierk, M. L., Smoot, M. E., Bass, E. J., and Pearson, W. R. (2010) “Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments.” BMC Bioinformatics 11:146.
Pearson, W. R. and Sierk, M. L. (2005) “The Limits of Protein Sequence Comparison?” Current Opinion in Structural Biology 15(3), 254-260.
Sierk, M. L. and Kleywegt, G. J. (2004) “Déjà vu all over again - Finding and Analyzing Protein Structure Similarities.” Structure 12, 2103-2111.
Sierk, M. L. and Pearson, W. R. (2004) “Sensitivity and selectivity in protein structure comparison.” Protein Science 13, 773-785.
Sierk, M. L., Zhao, Q., and Rastinejad, F. (2001) “DNA deformability as a recognition feature in the RevErb response element.” Biochemistry 40, 12833-12843.
Zhao, Q., Chasse, S. A., Devarakonda, S., Sierk, M. L., Ahvazi, B., and Rastinejad, F. (2000) “Structural basis of RXR-DNA interactions.” J. Mol. Biol. 296, 509-520.