Education

B.A. Biology The College of Wooster 1982
M.S. Biology The Catholic University of America 1989
Ph.D. Biology The Catholic University of America 1991

Courses Taught

BL 112     Understanding Biotechnology
BL 152     General Biology II
BL 153     General Biology II Laboratory
BL 208     Cell Biology
BL 209     Cell Biology Laboratory
BL 214     Molecular Genetics
BL 215     Molecular Genetics Laboratory
BL 216     Biotechnology
BL 217     Biotechnology Laboratory
BL 301     Junior Research Seminar
BL 302     Research Project
BL 303     Research Thesis

Research Interests

Molecular factors in Alzheimer's Disease progression
Genetics of volatile anesthetic sensitivity
Prion biology
Multi-Drug resistance
Genetics of Aging
Site-specific recombination based gene delivery systems
Mechanisms of homologous recombination

Experimental Model Systems

Cutured Mammalian Cells
The baker's yeast, Saccharomyces cerevisiae
Various bacterial species
Rats
Mice

Grants

Principal Investigator, National Science Foundation, Course Curriculum Laboratory Improvement (NSF-CCLI) Award #0510230 “Improving Quantitative Literacy Across The Natural Science Curriculum Through Digital Imaging Technology”, 2005

LI-COR Genomics Education Matching Fund Grant , 2005

Publications

Soukharev, S.; Berlin, W.; Hanover, J. A.; Bethke, B. and B. Sauer. (2000) Organization of the mouse ASGR1 gene encoding the major subunit of the hepatic asialoglycoprotein receptor. Gene 241:233-240.

Bethke, B. D. and B. Sauer (2000) Rapid generation of isogenic mammalian cell lines expressing recombinant transgenes by use of Cre recombinase. Methods in Molecular Biology 133:75-84.

Le, Y.; Gagneten, S.; Tombaccini, D.; Bethke, B. and B. Sauer. (1999) Nuclear targeting determinants of the phage P1 Cre DNA recombinase. Nucleic Acids Research 27 (24):4703-4709.

Bethke, B. D. and B Sauer (1997) Segmental genomic replacement by Cre-mediated recombination: genotoxic stress activation of the p53 promoter in single-copy transformants. Nucleic Acids Research 25 (14):2828-34.

Bethke, B. D. and J. Golin. (1994) Long tract mitotic gene conversion in yeast: Evidence for a triparental contribution during spontaneous recombination. Genetics 137(2):439-453.

Honors and Awards

Thoburn Award for Teaching Excellence 2006

Who’s Who Among America’s Teachers 2002

Quentin Schaut Faculty Award 2002

Genetics Society of America Travel Award Scholarship 1988

Sigma Xi chapter research grant 1987