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Michael Sierk Ph.D.

Assistant Professor, Bioinformatics

Michael Sierk


  • Ph.D., University of Virginia
  • B.S., Rice University
  • Courses

  • Biochemistry
  • Bioinformatics, Genomics, and Proteomics
  • Biomedical Informatics
  • General Chemistry I and lab
  • General Chemistry II Lab
  • Genes, Cells, and Computers
  • Junior Bioinformatics Seminar
  • Senior Bioinformatics Research
  • Senior Bioinformatics Seminar
  • Publications

    • Sierk, M. L., Smoot, M. E., Bass, E. J., and Pearson, W. R. (2010) "Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments." BMC Bioinformatics 11:146.
    • Pearson, W. R. and Sierk, M. L. (2005) "The Limits of Protein Sequence Comparison?" Current Opinion in Structural Biology 15(3), 254-260.
    • Sierk, M. L. and Pearson, W. R. (2004) "Sensitivity and selectivity in protein structure comparison." Protein Science 13, 773-785.
    • Sierk, M. L., Zhao, Q., and Rastinejad, F. (2001) "DNA deformability as a recognition feature in the RevErb response element." Biochemistry 40, 12833-12843.
    • Zhao, Q., Chasse, S. A., Devarakonda, S., Sierk, M. L., Ahvazi, B., and Rastinejad, F. (2000) "Structural basis of RXR-DNA interactions." J. Mol. Biol. 296, 509-520.
    • Sierk, M. L. and Kleywegt, G. J. (2004) “Déjà vu all over again - Finding and Analyzing Protein Structure Similarities.” Structure 12, 2103-2111.