Reestablishment of the Gut Microbiome following Antibiotic Treatment with Probiotic Bacteria
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A disruption, or dysbiosis, of the homeostatic conditions of the gut microbiome can occur from infection or subsequent treatment like antibiotics (Buret, et al, 2019; Francino, 2015). Probiotic bacteria, such as Lactobacillus species, can restore the gut microbiome (Khavari-Daneshvar, et al, 2017). In this study, probiotic supplement on antibiotic-treated rats was tested to see if the microbiome could be restored. Sixteen rats were separated into: no treatment, probiotic supplements, antibiotic-injections, and probiotic-plus-antibiotic injection. Two bacteria colonies were discovered. Colony 1 had significantly higher concentration (p=0.0015) than Colony 2. However, contrary to predictions, rats injected with antibiotics had a higher concentration of bacteria found in their cecum compared to the other three groups. The data also showed a positive correlation between the cecum weight and number of cecum bacteria. Overall, this study did not offer positive support for probiotic use.
Dr. Jennifer Koehl